Medicinal Cannabis & CBD
Evidence-based cannabinoid protocols for 30+ health conditions — including FDA-approved applications, clinical dosing guidance, drug interaction warnings, and peer-reviewed research on CBD and THC.
3
FDA-approved cannabinoids
30+
Conditions with evidence
30+
Countries approve Sativex
RCT-backed
Evidence standard
Conditions with Cannabinoid Evidence
43 conditions with clinical or preclinical cannabinoid evidence — each linked to its full nutraceutical protocol.
CBD Dosage & Delivery Guide
General dosing ranges from clinical literature. Always start low and titrate up. Consult a physician for therapeutic protocols.
| Form | Dose Range | Onset | Duration | Best For |
|---|---|---|---|---|
| CBD Oil (sublingual) | 10–100mg/day | 15–45 min | 4–6 hours | Anxiety, sleep, inflammation, general wellness |
| CBD Capsules | 15–50mg/day | 30–90 min | 6–8 hours | Consistent daily dosing, chronic conditions |
| Topical CBD Cream | 50–150mg/application | 15–30 min | 4–6 hours | Localized pain, skin conditions, arthritis |
| CBD:THC 1:1 (Sativex) | Per physician protocol | 15–40 min | 4–6 hours | MS spasticity, neuropathic pain (prescription) |
| Full-Spectrum CBD | 25–75mg/day | 15–45 min | 4–6 hours | Entourage effect; anxiety, pain, inflammation |
CBD & Cannabis Drug Interactions
CBD inhibits CYP2C9 and CYP3A4 liver enzymes. Always disclose cannabis use to your physician and pharmacist.
Warfarin / Blood thinners
CBD inhibits CYP2C9 — significantly increases warfarin levels; monitor INR closely
Antiepileptics (clobazam, valproate)
CBD increases clobazam levels via CYP2C19 inhibition; monitor for sedation
Immunosuppressants (tacrolimus, cyclosporine)
CBD inhibits CYP3A4 — may increase drug levels; monitor drug concentrations
SSRIs / Antidepressants
CBD may increase serotonin activity; monitor for serotonin syndrome symptoms
Blood pressure medications
THC may cause tachycardia and blood pressure changes; CBD may lower BP
Sedatives / Benzodiazepines
Additive CNS depression; reduce doses cautiously under physician guidance
Key Research Findings
CBD (Epidiolex) reduces seizure frequency by 39% in Dravet syndrome — FDA approved
Devinsky et al., NEJM, 2017
Sativex (CBD:THC 1:1) significantly reduces MS spasticity — approved in 30+ countries
Collin et al., European Journal of Neurology, 2007
CBD reduces anxiety in simulated public speaking test in RCT (300mg dose)
Bergamaschi et al., Neuropsychopharmacology, 2011
CBD reduces sebocyte lipid synthesis and C. acnes inflammation via CB2 receptors
Oláh et al., Journal of Clinical Investigation, 2014
Dronabinol (synthetic THC) significantly reduces chemotherapy-induced nausea — FDA approved
Sallan et al., NEJM, 1980
Cannabis use associated with significant pain reduction in chronic pain patients across 28 studies
Aviram & Samuelly-Leichtag, Journal of Pain Research, 2017
Frequently Asked Questions
What conditions is medicinal cannabis approved for?
FDA-approved cannabinoid medications include: Epidiolex (CBD) for Dravet syndrome and Lennox-Gastaut epilepsy, Marinol/Syndros (dronabinol/synthetic THC) for chemotherapy-induced nausea and AIDS-related anorexia, and Cesamet (nabilone) for chemo nausea. Sativex (CBD:THC 1:1) is approved in 30+ countries for MS spasticity.
What is the difference between CBD and THC?
CBD (cannabidiol) is non-psychoactive with anti-inflammatory, anxiolytic, and anticonvulsant properties. THC (tetrahydrocannabinol) is psychoactive with analgesic, antiemetic, and appetite-stimulating effects. Many conditions benefit from both together (entourage effect), while others respond better to CBD alone.
Does CBD interact with medications?
Yes — CBD inhibits CYP2C9 and CYP3A4 liver enzymes, which can significantly increase levels of warfarin, antiepileptics (clobazam, valproate), immunosuppressants (tacrolimus, cyclosporine), and many other medications. Always consult a physician before combining CBD with prescription medications.
How do I find the right CBD dosage?
Start low (5–10mg/day) and increase by 5–10mg every 1–2 weeks until desired effect. General ranges: anxiety 25–75mg/day, chronic pain 25–100mg/day, sleep 25–50mg before bed, epilepsy 2–10mg/kg/day (physician supervised). Sublingual oil has faster onset than capsules.
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